WASHINGTON -- Wilmer Difo hit his first major league homer, and Pedro Severino his second, helping the injury-depleted NL East champion Washington Nationals move closer to clinching home-field advantage in the Division Series by beating the Arizona Diamondbacks 5-3 at a near-empty stadium on a dreary Thursday.Second baseman Difo and catcher Severino, both rookies, were in the lineup instead of Daniel Murphy (last started 12 days ago) and Wilson Ramos (out for the season), respectively.Last in the NL West, Arizona has nothing at stake the rest of the way. The Nationals, while already assured of winning their division and of facing the Los Angeles Dodgers to open their postseason, still are trying to lock up a higher seeding for that series.Washington began Thursday with a two-game lead over NL West champion LA for the right to host more games in the best-of-five NLDS. The Dodgers, though, hold the tiebreaker because of a 5-1 advantage in the teams season series.Nationals starter Joe Ross, working his way back from a stay on the disabled list with right shoulder inflammation, allowed one run in four innings, throwing 90 pitches. Washington wants to stretch him out to be able to start at some point in the playoffs.Reliever Reynaldo Lopez (5-3) was credited with the win. He pitched 3 2/3 innings, letting up Socrates Britos two-run homer in the ninth before being lifted.Mark Melancon got the last two outs for his 45th save.Robbie Ray (8-15) allowed five runs in 4 2/3 innings, including solo shots by Severino in the third and Difo in the fifth, along with Michael A. Taylors two-run single in the fourth.TRAINERS ROOMDiamondbacks: RF Yasmany Tomas was a late scratch from the starting lineup because of a stiff neck.Nationals: 2B Murphy (glute muscle) and RF Bryce Harper (left thumb) sat out again. Manager Dusty Baker said he expects to get Murphy back in the starting lineup for Game 1 of the NLDS against the Dodgers on Oct. 7. Murphy last began a game on Sept. 17. He might get a pinch-hit, but I dont want to take him backwards, Baker said. Well probably have an intrasquad game or something to get him some live pitching.Harper, meanwhile, was out of the lineup for a fourth consecutive day, but mainly as a precaution on a wet day. Im still a little afraid. If he hits the ball solid, its not going to hurt. But if he gets rattled or hits one on the end or gets jammed on one, its going to send electric shocks through his body, Baker said.RAMOS STOPS BYRamos, out for the rest of 2016 because of a torn ACL in his right knee, stopped by the home clubhouse before Thursdays game. He is waiting for the swelling in his knee to go down before having surgery. Asked whether he would be around the Nationals during the playoffs, Ramos said: Im going to have to support the team from home, because its going to be very difficult for me to get around with the knee after the surgery.Ramos can become a free agent this offseason, and reportedly turned down a contract offer before he got hurt.If its up to me, he said Thursday, I definitely would like to keep playing for the Nationals and play as long as I can.UP NEXTDiamondbacks: Open a season-closing, three-game home series against the San Diego Padres, with RHP Braden Shipley (4-5, 5.26 ERA) starting for Arizona on Friday. The Diamondbacks and Padres are two of the four worst teams in the NL.Nationals: Their final regular-season series begins Friday against the visiting Miami Marlins. RHP A.J. Cole (1-2, 5.09) is slated to pitch for Washington, but he is waiting to hear the outcome of his appeal of a five-game suspension for throwing at a batter. Tanner Lee Hoodie . 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